Pharmacotherapy In Childhood  and Adolescent Obesity

Pharmacotherapy In Childhood  and Adolescent Obesity

Mahtab Niroomand M.D.

Assistant professor of Endocrinology

SBUMS

• Pharmacotherapy in childhood  and adolescent obesity:
  • Why ?
  • What?
  • When?
• Why do obese people have difficulty losing weight or sustaining weight loss?
  •  Time commitments
  •  Costs of lifestyle changes
  • Biological considerations

• Sibutramine acts:
  •  Centrally to:
    •  Inhibit reuptake of serotonin, norepinephrine,

   and, to a lesser extent, dopamine. It reduces hunger and increases satiety,

• •   In brown adipose tissue:
    •  Promotes thermogenesis,which increases energy expenditure
• Rapid absorption , peak plasma  concentration are reached within one or two hours